Lus piav qhia luv luv:
CAS Nr .: 54965-21-8
Cov mis mos molecular: C12H15N3O2S
Molecular Luj: 265.333
Chemical structure:
Kev piav qhia
Albendazole (ALBENZA) yog ib qho tshuaj noj broad-spectrum anthelmintic. Albendazole chewable ntsiav tshuaj muaj nyob rau hauv Lub Koom Haum Ntiaj Teb Kev Noj Qab Haus Huv (WHO) cov npe ntawm cov tshuaj tseem ceeb ua cov tshuaj tua kab mob hauv plab thiab tshuaj tua kab mob. Albendazole ntsiav tshuaj tau tsim los ntawm SmithKline Animal Health Laboratories thiab tau pom zoo los ntawm US Food and Drug Administration (FDA) xyoo 1996.
Albendazole muaj peev xwm tua tag nrho cov qe ntawm whipworm thiab hookworm thiab ib nrab tua Ascaris 'qe; Nws tseem tuaj yeem tshem tawm ntau hom nematodes parasitizing hauv cov tsiaj lub cev, thiab muaj kev cuam tshuam rau kev tshem tawm lossis ncaj qha tua kab mob tapeworms thiab cysticerci. Nws yog li no pab tau nyob rau hauv kev kho mob ntawm hydatid thiab lub paj hlwb (cysticercosis) tshwm sim los ntawm kab mob ntawm cov nqaij npuas worm, thiab kuj nyob rau hauv kev kho mob ntawm hookworm, roundworm, pinworm, nematode trichinella, tapeworm, whipworm thiab stercoralis nematode.
Pharmacodynamics
Albendazole yog ib hom benzimidazole derivatives. Nws yog metabolized sai sai hauv vivo rau hauv sulfoxide, sulfone thiab 2-polyamine sulfone cawv. Nws muaj peev xwm xaiv thiab irreversibly suppress lub qabzib uptake ntawm plab hnyuv nematodes, yog li ua rau endogenous glycogen depletion ntawm tus cab; Nyob rau tib lub sijhawm, nws kuj inhibit qhov kev ua ntawm fumarate reductase, thiab yog li tiv thaiv kev tsim ntawm adenosine triphosphate, thaum kawg ua rau cov kab mob tuag taus.
Zoo ib yam li mebendazole, los ntawm kev ua rau lub denaturation ntawm cytoplasmic microtubules ntawm plab hnyuv parasites thiab khi rau tubulin, nws ua rau clogging ntawm intracellular thauj, ua rau tsub zuj zuj ntawm Golgi endocrine hais; cytoplasm yog ntxiv maj mam yaj, ua rau qhov kawg tuag ntawm cov cab.
Cov khoom no tuaj yeem tua cov qe qe, pinworm qe, spin wool qe, tapeworm qe thiab cysticercosis nplawm qe thiab ib nrab tua Ascaris 'qe.
Siv dav
Albendazole yog ib qho tshuaj siv los kho cov kab mob los ntawm cov kab mob cab. Nws tuaj yeem muab los kho mob hlwb tsis tshua muaj kab mob (neurocysticercosis) lossis nws tuaj yeem muab los kho tus kab mob cab uas ua rau mob plab tseem ceeb (microsporidiosis).
Kev siv tshuaj kho mob
Albendazole muaj ntau yam kev ua haujlwm tawm tsam plab hnyuv nematodes thiab cestodes, nrog rau lub siab flukes Opisthorchis sinensis, Opisthorchis viverrini, thiab Clonorchis sinensis. Nws kuj tau siv tau zoo tiv thaiv Giardia lamblia. Nws yog dav siv thoob plaws lub ntiaj teb no rau kev kho mob ntawm plab hnyuv nematode. Nws muaj txiaj ntsig zoo li kev kho mob ib zaug rau ascariasis, New thiab Old World hookworm kab mob, thiab trichuriasis. Kev kho ntau yam nrog albendazole caneradicate pinworm, threadworm, capillariasis, clonorchiasis, thiab kab mob hydatid. Kev ua tau zoo ntawm albendazole tiv thaiv kab mob tapeworms (cestodes) feem ntau yog qhov sib txawv thiab tsis zoo. Nws kuj tseem siv tau zoo hauv kev kho mob cerebral thiab spinal neurocysticercosis, tshwj xeeb tshaj yog thaum muab nrog dexamethasone.Albendazole tau pom zoo rau kev kho mob gnathostomiasis.
