Lus piav qhia luv luv:
CAS nr:590-63-6 : kuv
Cov mis mos molecular:C7H17ClN2O2
Molecular Luj:196.68 ib
Chemical structure:
| Cov ntaub ntawv yooj yim | |
| Khoom npe | Bethanechol |
| Qib | Pharma qib |
| Qhov tshwm sim | hmoov dawb |
| Assay | 95% |
| Txee lub neej | 2 xyoo |
| Ntim | 25kg / nruas |
| Qhov xwm txheej | Txias thiab qhuav qhov chaw |
Kev piav qhia
Bethanechol yog ib qho hluavtaws ester structurally thiab pharmacologically cuam tshuam rau acetylcholine. Ib qho maj mam hydrolyzed muscarinic agonist uas tsis muaj cov teebmeem nicotinic, bethanechol feem ntau yog siv los ua kom cov leeg nqaij du, xws li hauv GI ib puag ncig tom qab phais plab lossis hauv qhov tso zis thaum tsis muaj kev cuam tshuam. Nws tuaj yeem ua rau hypotension, hloov pauv plawv, thiab bronchial spasms.
Bethanechol yog ib tug agonist ntawm muscarinic acetylcholine receptors nrog IC50 qhov tseem ceeb ntawm 1,837, 25, 631, 317, thiab 393 μM rau M1-5, raws li, nyob rau hauv ib tug radioligand binding assay siv CHO hlwb qhia cov tib neeg receptors. Nws inhibits M2-mediated nce nyob rau hauv cyclic AMP induced los ntawm isoproterenol nyob rau hauv cais guinea npua cov hnyuv (IC50 = 127 μM). Bethanechol nce basal suab nrov ntawm cov porcine intravesical ureter (EC50 = 4.27 μM). Nws kuj tseem ua rau cov kua dej tso tawm hauv ileum, duodenum, thiab jejunum ntawm cov nas tsuag tshuaj loog thaum muab tshuaj ntawm 60 μg / kg. Cov qauv uas muaj bethanechol tau siv los ua kom tso zis thiab txhim kho cov leeg nqaij du hauv plab hnyuv.
Kev siv tshuaj kho mob
Kev siv tseem ceeb ntawm bethanechol chloride yog nyob rau hauv kev kho mob ntawm urinary retention thiab mob plab tom qab phais.Cov tshuaj yog siv los ntawm qhov ncauj thiab los ntawm kev txhaj tshuaj subcutaneous. Nws yuav tsum tsis txhob muab tshuaj los ntawm intramuscular lossis intravenousinjection vim tias muaj kev phom sij los ntawm cholinergic overstimulation thiab poob ntawm kev xaiv. Kev tswj hwm ntawm cov tshuaj raug cuam tshuam nrog cov tshuaj toxicity tsawg thiab tsis muaj kev phiv loj. Bethanechol chloride yuav tsum tau siv nrog ceev faj cov neeg mob inasthmatic; Thaum siv rau glaucoma, nws ua rau mob taub hau los ntawm constriction ntawm sphinctermuscle nyob rau hauv lub qhov muag thiab los ntawm ciliary nqaij spasms. Nws lub sijhawm ua haujlwm yog 1 teev.
Veterinary tshuaj thiab kev kho mob
Hauv cov kws kho tsiaj, bethanechol yog siv feem ntau los txhawb lub zais zis hauv cov tsiaj me. Nws kuj tseem tuaj yeem siv los ua cov tshuaj esophageal lossis GI stimulant, txawm hais tias metoclopramide thiab / lossis neostigmine tau hloov pauv ntau rau cov kev siv no.
