Lus piav qhia luv luv:
CAS Nr .: 472-15-1
Cov mis mos molecular: C30H48O3
Molecular Luj: 456.71
Chemical structure:
| Cov ntaub ntawv yooj yim | |
| Khoom npe | Betulinic acid |
| Qib | Pharma qib |
| Qhov tshwm sim | Dawb los yog dawb dawb |
| Assay | 98% |
| Txee lub neej | 2 xyoo |
| Ntim | 25kg / nruas |
| Qhov xwm txheej | Stable, tab sis cia txias. Incompatible nrog muaj zog oxidizing neeg sawv cev, calcium gluconate, barbiturates, magnesium sulfate, phenytoin, B pab pawg neeg sodium vitamins. |
Kev piav qhia
Betulinic acid (472-15-1) yog lub ntuj Lupane triterpenoid los ntawm ntoo birch dawb (Betula pubescens). Induces apoptosis nyob rau hauv ntau hom cell kab.1 Induces mitochondrial permeability hloov pore qhib.2 ?Ua raws li ib tug chemosensitizer rau anticancer tshuaj kho nyob rau hauv chemoresistant colon cancer cell kab.3 Cell permeable.
Siv
Betulinic Acid yog lub ntuj pentacyclic triterpenoid. Betulinic Acid qhia txog kev tiv thaiv kab mob thiab tiv thaiv kab mob HIV. Betulinic Acid xaiv induces apoptosis nyob rau hauv cov qog hlwb los ntawm ncaj qha activating lub mitochondrial txoj kev ntawm apoptosis los ntawm ib tug p53- thiab CD95-kev ywj pheej mechanism. Betulinic Acid kuj nthuav tawm TGR5 agonist kev ua haujlwm.
Betulinic acid (BetA) tau siv:
1.Kom kuaj nws cov teebmeem raws li tus neeg sawv cev tiv thaiv kab mob tiv thaiv tus kab mob Dengue (DENV).
2.raws li sterol regulatory element-binding protein (SREBP) inhibitor los tswj cov lipid metabolism thiab proliferation ntawm ntshiab cell cell carcinoma (ccRCC) hlwb.
3.raws li kev kho mob los sim nws cov khoom tiv thaiv qog nqaij hlav rau cov cell viability thiab apoptotic cell tuag kev soj ntsuam hauv ntau tus qauv myeloma.
Kev tshawb nrhiav Anticancer
Cov tshuaj no yog pentacyclic triterpene tau los ntawm Betula thiab Zizyphus hom, uas qhia tau hais tias xaiv cytotoxicity tawm tsam tib neeg melanoma hlwb (Shoeb2006). Nws generates reactive oxygen hom, activates MAPK cascade, inhibitstopoisomerase I, inhibits angiogenesis, modulates pro-growth transcriptionalactivators, modulates cov kev ua ntawm aminopeptidase-N, thiab yog li inducesapoptosis nyob rau hauv cov qog nqaij hlav cancer (Desai li al. 2008; Fulda 2008).
Kev ua lom lom
Ntuj triterpenoid uas qhia txog kev tiv thaiv kab mob HIV thiab tshuaj tiv thaiv kab mob. Induces zus tau tej cov reactive oxygen hom (ROS) thiab activates NF- κ B. Exhibits TRG5 agonist kev ua si (EC 50 = 1.04 μ M).
Biochem/physiol Actions
Betulinic acid, ib tug pentacyclic triterpene, xaiv induces apoptosis nyob rau hauv cov qog hlwb los ntawm ncaj qha activating lub mitochondrial txoj kev ntawm apoptosis los ntawm ib tug p53- thiab CD95-kev ywj pheej mechanism.
