Lus piav qhia luv luv:
CAS Nr .: 38821-53-3
Cov mis mos molecular: C16H19N3O4S
Molecular Luj: 349.4
Chemical structure:
| Cov ntaub ntawv yooj yim | |
| Khoom npe | Cefradine |
| Kev ruaj ntseg | Lub teeb Sensitive |
| Qhov tshwm sim | Dawb hmoov |
| Assay | 99% |
| Melting point | 140-142 C ib |
| Ntim | 5kg; 1 ygo |
| Boiling point | 898 ℃ |
Kev piav qhia
Cefradine (tseem hu ua cephradine), 7-[D-2-amino-2(1,4cyclohexadien1-yl) acetamido]-3-methyl-8-0x0-5thia-l-azabicyclo[4.2.0] oct-2- ene-2-carboxylic acid monohydrate (111 yog ib qho tshuaj tua kab mob semi-synthetic cephalosporin. siv qhov ncauj, intramuscularly, thiab intravenously. Cov qauv ntawm cephradine zoo ib yam li cephalexin, qhov sib txawv tsuas yog nyob rau hauv lub nplhaib rau-tus tswv cuab. Cephalexin muaj peb. ob daim ntawv cog lus tsim lub cev muaj zog thaum cephradine muaj ob daim ntawv cog lus hauv tib lub nplhaib Cov tshuaj tua kab mob ntawm cephradine zoo ib yam li cephalexin[1].
Daim duab 1 cov qauv tshuaj ntawm cefradine;
Cephradine yog cov hmoov dawb crystalline hmoov nrog qhov hnyav ntawm 349.4[2]. Lub synthesis ntawm cephradine tau tham[3]. Cephradine yog dawb do soluble nyob rau hauv aqueous kuab tshuaj. Nws yog zwitterion, muaj ob qho tib si alkaline amino pawg thiab ib pawg acidic carboxyl. Hauv pH ntau ntawm 3-7, cephradine muaj nyob hauv cov ntsev sab hauv[4]. Cephradine ruaj khov rau 24 hr ntawm 25 "nyob rau hauv lub pH ntau ntawm 2-8. Txij li thaum nws ruaj khov nyob rau hauv acidic media, muaj me ntsis poob ntawm kev ua si nyob rau hauv lub gastric kua; poob ntawm tsawg tshaj li 7% tau tshaj tawm.[5].
Cephradine tsis muaj zog khi rau tib neeg cov ntshav cov protein. Cov tshuaj yog tsawg dua 20% khi rau cov ntshav cov protein[4]. Nyob rau hauv cov ntshav concentration ntawm 10-12 pg / ml, 6% ntawm tag nrho cov tshuaj yog nyob rau hauv cov protein-bound complex. Lwm txoj kev kawm[6]pom tias ntawm tag nrho cov concentration ntawm 10 pg / ml, 28% ntawm cov tshuaj yog nyob rau hauv lub xeev ntawm cov protein; ntawm tag nrho cov concentration ntawm 100 pg / ml, 30% ntawm cov tshuaj yog nyob rau hauv lub xeev ntawm cov protein. Txoj kev tshawb no kuj tau pom tias ntxiv cov ntshav rau cephradine txo cov tshuaj tua kab mob. Lwm txoj kev kawm[2]qhia tau hais tias cov protein khi ntawm cephradine txawv ntawm 8 mus rau 20%, nyob ntawm qhov concentration ntawm cov tshuaj. Txawm li cas los xij, kev tshawb fawb los ntawm Gadebusch li al.[5]pom tsis muaj kev hloov pauv hauv MIC ntawm cephradine mus rau Staphylococcus aureus lossis Escherichia coli tom qab ntxiv cov ntshav hauv tib neeg.
Cov lus qhia
Cephradine yog nquag nyob rau hauv vitro tiv thaiv ib tug dav spectrum ntawm gram-positive thiab gram-negative kab mob, nrog rau cov kab mob pathogenic cais nyob rau hauv lub chaw kho mob; Cov compound tau pom tias yog cov kua qaub ruaj khov, thiab qhov sib ntxiv ntawm tib neeg cov ntshav tau tsuas yog cuam tshuam me ntsis ntawm qhov tsawg kawg nkaus inhibitory concentration (MIC) rau cov kab mob rhiab heev. Thaum muab qhov ncauj lossis subcutaneously rau cov tsiaj uas kis tau nrog ntau yam kab mob pathogenic, cephradine muaj kev tiv thaiv zoo.[16]. Hauv kev kho mob ntawm cov kab mob sib kis tau zoo, cov lus teb zoo rau kev kho mob cephradine tau tshaj tawm los ntawm ntau tus kws tshawb fawb.[14, 15, 17-19].
