Lus piav qhia luv luv:
CAS Nr .: 1264-72-8
Cov mis mos molecular: 2 (C52H98N16O13.5(H2SO4)
Molecular Luj: 2801.27
Chemical structure:
| Cov ntaub ntawv yooj yim | |
| Khoom npe | Colistin sulfate |
| Qib | Pub Qib |
| Qhov tshwm sim | Dawb los yog yuav luag dawb, hygroscopic hmoov |
| Assay | 99% |
| Txee lub neej | 2 xyoo |
| Ntim | 20kg / carton 20kg / nruas |
| Qhov xwm txheej | Khaws ntawm -20 ℃ rau ib xyoos(Hmoov) |
Cov lus piav qhia ntawm cov khoom
Colistin yog ib qho cyclic cationic decapeptide txuas rau cov kab mob fatty acid, nws yog ib pawg ntawm cov kab mob zoo sib xws ntawm cov kab mob antimicrobial peptides. Colistin sulfate yog polypeptide tshuaj tua kab mob uas inhibits gram-tsis zoo cov kab mob los ntawm kev khi rau lipopolysaccharides thiab phospholipids nyob rau hauv lub cell membrane ntawm gram-negative kab mob.
Colistin sulfate, tseem hu ua colistin sulfate, Christian (Colistin), Polymyxin E (Polymyxin E), antiphytin, dawb los yog ze li ntawm cov hmoov dawb, tsis muaj ntxhiab, iab saj moistness, yooj yim soluble hauv dej, me ntsis soluble hauv methanol, ethanol, yuav luag insoluble hauv acetone, ether, dawb alkali me ntsis soluble hauv dej. Kev ruaj khov hauv PH3-7.5 ntau yam. Mycolistin sulfate yog tsim los ntawm Bacillus polymyxoides, uas muaj zog tiv thaiv kab mob ntawm cov kab mob gram-tsis zoo. Nws yog siv los kho cov kab mob hauv plab uas tshwm sim los ntawm cov kab mob gram-tsis zoo, thiab siv los ua cov khoom noj ntxiv nrog pom tseeb kev loj hlob txhawb nqa. Kev sib xyaw ua ke ntawm sulfadiazine nyhuv zoo dua.
Kev ua haujlwm ntawm cov khoom
Colistin sulfate granules txhim kho nyob rau hauv kev ruaj ntseg ntawm potency nyob rau hauv pub thiab exhibiting siab solubility nyob rau hauv txawm hais tias lawv raug tsim tsis siv tej khoom kim kim los yog khoom tshwj xeeb. Tshwj xeeb, colistin sulfate granules muaj qhov tseem ceeb ntawm colistin sulfate thiab muaj particle diameters ntawm 150 mus rau 1500m, ib cheeb tsam tshwj xeeb ntawm 40 mus rau 500 cm2 / g, lub sij hawm ntub dej ntawm 5 feeb lossis qis dua thiab cov ntsiab lus noo ntawm 10% lossis qis dua.
Pharmacodynamics
Colistin yog polymyxin tshuaj tua kab mob. Polymyxins yog cationic polypeptides uas cuam tshuam cov kab mob cell membrane los ntawm ib tug detergentlike mechanism. Nrog rau kev txhim kho cov tshuaj lom neeg tsawg, xws li txuas ntxiv-spectrum penicillins thiab cephalosporins, kev siv parenteral polymyxin feem ntau raug tso tseg, tshwj tsis yog rau kev kho mob ntawm ntau cov kab mob pulmonary-resistant rau cov neeg mob cystic fibrosis.
