Lus piav qhia luv luv:
CAS Nr .: 15687-27-1
Cov mis mos molecular: C13H18O2
Molecular Luj: 206.28
Chemical structure:
| Cov ntaub ntawv yooj yim | |
| Khoom npe | Ibuprofen |
| CAS Nr. | 15687-27-1 |
| Xim | Dawb mus rau dawb |
| Daim ntawv | Crystalline hmoov |
| Solubility | Xyaum insoluble hauv dej, dawb soluble hauv acetone, hauv methanol thiab hauv methylene chloride. Nws dissolves nyob rau hauv dilute daws ntawm alkali hydroxides thiab carbonates. |
| Dej Solubility | insoluble |
| Kev ruaj ntseg | ruaj khov. Hluav taws kub. Incompatible nrog muaj zog oxidizing neeg sawv cev |
| Txee lub neej | 2 Ypob ntseg |
| Pob | 25kg / Nruas |
Kev piav qhia
Ibuprofen belongs rau non-steroidal anti-inflammatory analgesic. Nws muaj cov nyhuv anti-inflammatory, analgesic thiab antipyretic zoo nrog cov tshuaj tsis zoo. Nws tau dav siv nyob rau hauv lub ntiaj teb no, raws li lub ntiaj teb no tus zoo tshaj plaws-muag tshuaj uas tsis yog tshuaj. Nws, ua ke nrog cov tshuaj aspirin thiab paracetamol tau teev tseg raws li peb qhov tseem ceeb antipyretic analgesics khoom. Nyob rau hauv peb lub teb chaws, nws yog tsuas yog siv nyob rau hauv mob alleviation thiab anti-rheumatism, thiab lwm yam. Nws muaj ntau tsawg daim ntaub ntawv nyob rau hauv kev kho mob khaub thuas thiab kub taub hau piv nrog paracetamol thiab aspirin. Muaj ntau lub tuam txhab tshuaj tsim nyog rau kev tsim ibuprofen hauv Suav teb. Tab sis feem ntau ntawm kev lag luam hauv tsev muag khoom ntawm ibuprofen tau tuav los ntawm Tianjin Sino-US Company.
Lub Ibuprofen tau tshawb pom los ntawm Dr. Stewart Adams (tom qab ntawd nws dhau los ua tus xibfwb thiab yeej tau txais txiaj ntsig ntawm lub tebchaws Askiv lub tebchaws) thiab nws pab neeg suav nrog CoLinBurrows thiab Dr. John Nicholson. Lub hom phiaj ntawm kev tshawb fawb thawj zaug yog los tsim "super aspirin" kom tau txais lwm txoj hauv kev kho mob rheumatoid mob caj dab uas piv rau cov tshuaj aspirin tab sis tsis tshua muaj tshwm sim tsis zoo. Rau lwm cov tshuaj xws li phenylbutazone, nws muaj kev pheej hmoo siab ua rau muaj kev tawm tsam adrenal thiab lwm yam teeb meem xws li mob plab hnyuv. Adams tau txiav txim siab los nrhiav cov tshuaj uas muaj cov kab mob plab zoo, uas yog qhov tseem ceeb tshwj xeeb rau txhua yam tshuaj uas tsis yog-steroidal anti-inflammatory.
Cov tshuaj Phenyl acetate tau ua rau tib neeg nyiam. Txawm hais tias qee yam ntawm cov tshuaj no tau pom tias muaj kev pheej hmoo ua rau mob raws li tus dev qhov kev sim, Adams paub tias qhov tshwm sim no yuav yog vim qhov ntev ib nrab-lub neej ntawm cov tshuaj tshem tawm. Nyob rau hauv cov chav kawm ntawm cov tshuaj no muaj ib tug compound - ibuprofen, uas muaj ib tug luv luv ib nrab-lub neej, txhawb nqa tsuas yog 2 teev. Ntawm cov tshuaj ntsuam xyuas lwm yam tshuaj, txawm tias nws tsis zoo tshaj plaws, nws yog qhov ruaj ntseg tshaj plaws. Xyoo 1964, ibuprofen tau dhau los ua lwm txoj hauv kev zoo tshaj plaws rau cov tshuaj aspirin.
Cov lus qhia
Lub hom phiaj tseem ceeb hauv kev txhim kho cov tshuaj kho mob thiab kho mob yog tsim cov tshuaj sib txuas uas muaj peev xwm kho mob, ua npaws, thiab mob yam tsis muaj kev cuam tshuam lwm yam kev ua haujlwm ntawm lub cev. Cov tshuaj kho mob dav dav, xws li tshuaj aspirin thiab ibuprofen, inhibit COX-1 thiab COX-2. Ib qho tshuaj tshwj xeeb rau COX-1 piv rau COX-2 txiav txim siab qhov muaj feem cuam tshuam rau kev phiv. Cov tshuaj uas muaj qhov tshwj xeeb dua rau COX-1 yuav muaj peev xwm ua rau muaj kev phiv ntau dua. Los ntawm deactivating COX-1, cov tshuaj tua kab mob tsis xaiv ua rau muaj feem cuam tshuam tsis zoo, tshwj xeeb tshaj yog cov teeb meem digestive xws li mob plab thiab plab hnyuv los ntshav. COX-2 inhibitors, xws li Vioxx thiab Celebrex, xaiv deactivate COX-2 thiab tsis cuam tshuam rau COX-1 ntawm cov tshuaj noj. COX-2 inhibitors yog dav siv rau kev mob caj dab thiab mob nyem. Xyoo 2004, Lub Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) tau tshaj tawm tias muaj kev pheej hmoo siab ntawm plawv nres thiab mob stroke yog txuam nrog qee yam COX-2 inhibitors. Qhov no tau ua rau cov ntawv ceeb toom thiab kev yeem tshem tawm cov khoom lag luam los ntawm cov neeg tsim tshuaj; Piv txwv li, Merck coj Vioxx tawm ntawm kev ua lag luam hauv xyoo 2004. Txawm hais tias ibuprofen inhibits COX-1 thiab COX-2, nws muaj ob peb zaug qhov tshwj xeeb rau COX-2 piv rau cov tshuaj aspirin, ua rau muaj kev phiv tsawg dua hauv plab hnyuv..
