Lus piav qhia luv luv:
CAS Nr .: 55268-74-1
Cov mis mos molecular: C19H24N2O2
Molecular Luj: 312.41
Chemical structure:
| Cov ntaub ntawv yooj yim | |
| Khoom npe | Praziquantel |
| Qib | Pharma qib |
| Qhov tshwm sim | Nws yog dawb los yog yuav luag dawb crystalline hmoov |
| Assay | 99% |
| Txee lub neej | 2 xyoo |
| Ntim | 25kg / nruas |
| Yam ntxwv | Dawb soluble nyob rau hauv ethanol los yog dichloromethane. Me ntsis soluble hauv dej |
| Qhov xwm txheej | Muab ntim rau hauv qhuav, Khaws rau hauv lub freezer, hauv qab -20 ° C |
Kev piav qhia
Praziquantel (PZQ) yog ib qho isoquinoline derivative nrog feem ntau ntawm cov kev ua lom neeg muaj nyob hauv levo enantiomer. Cov compound tsis muaj kev ua haujlwm tawm tsam nematodes, tab sis nws muaj txiaj ntsig zoo tiv thaiv cestodes thiab trematodes.
Pharmacology thiab mechanism ntawm kev txiav txim
Praziquantel yog ib qho pyrazinoquinoline compound Ameslikas tsim rau kev kho mob schistosomiasis tab sis tau pom tias muaj ntau yam kev ua anthelminthic. Praziquantel yog ib haiv neeg sib tw tab sis R (+) enantiomer tsuas yog lub luag haujlwm rau nws cov tshuaj tiv thaiv kab mob. Nws yog nquag tawm tsam trematodes (tag nrho cov kab mob Schistosoma pathogenic rau txiv neej, Paragonimus westermani, thiab Clonorchis sinensis) thiab cestodes (Taenia saginata, Taenia solium, Hymenolepis nana thiab Diphyllobothrium latum).
Lub mechanism ntawm kev txiav txim ntawm praziquantel tsis paub meej. Schistosomes noj cov tshuaj sai sai. Kev noj tshuaj yog tam sim ntawd ua raws li cov leeg nqaij uas nce mus rau tetanic contraction thiab vacuolization ntawm parasite tegument .
Cov leeg nqaij ntawm cov tshuaj tau suav tias yog lub luag haujlwm rau kev hloov pauv ntawm cov cab los ntawm cov hlab ntsha mesenteric mus rau daim siab hauv vivo. Txawm li cas los xij, kev hloov pauv hauv siab tau pom tau tias feem ntau paub txog schistosomicides thiab tej zaum yuav tsis muab cov ntaub ntawv tshwj xeeb ntawm cov tshuaj cov txheej txheem ntawm kev ua. Cov kev tshawb pom tsis ntev los no tau pom tias cov teebmeem antischistosomal ntawm cov tshuaj muaj feem xyuam rau nws cov nyhuv ntawm tesument es tsis yog ntawm cov leeg nqaij.
Lwm cov nyhuv pharmacological ntawm cov tshuaj suav nrog kev nce ntawm daim nyias nyias permeability rau cations, tshwj xeeb tshaj yog calcium.
Txawm li cas los xij, lub luag haujlwm ntawm cov nyhuv no rau cov cuab yeej anthelminthic ntawm cov tshuaj tsis paub.
Daim ntawv thov
Nws yog ib hom dav-spectrum tshuaj tiv thaiv kab mob parasitic. Nws tuaj yeem siv rau kev kho mob thiab tiv thaiv kab mob schistosomiasis, cysticercosis, paragonimiasis, kab mob hydatid, fasciolopsiasis, kab mob hydatid, thiab kab mob cab.
Nws kuj tseem siv tau los ua anthelmintic thiab muaj txiaj ntsig zoo hauv kev kho tsiaj kab mob plab nematodes. Nws tuaj yeem muab sib xyaw rau hauv qhov pub rau daim ntawv thov.
Cov khoom no yog ib hom tshuaj anthelmintic siv tau los kho Schistosoma japonicum, Schistosoma mansoni thiab Schistosoma haematobium, Clonorchis sinensis, Paragonimus westermani, fasciolopsis buski, tapeworms thiab cysticercosis. Nws muaj qhov tshwj xeeb muaj zog tua cov nyhuv ntawm tapeworm thiab tam sim no ntawm kev ua tau zoo tshaj plaws ntawm cov tshuaj tiv thaiv schistosomiasis.
Nws yog ib hom tshuaj anthelmintics feem ntau siv los kho tus mob schistosomiasis. Nws tuaj yeem siv los kho Fahrenheit schistosomiasis, taeniasis, paragonimiasis, thiab cysticercosis
