Lus piav qhia luv luv:
CAS nr:51322-75-9
Cov mis mos molecular:C9H8ClN5S
Molecular Luj:253.71 ib
Chemical structure:
| Cov ntaub ntawv yooj yim | |
| Khoom npe | Tizanidine |
| Qib | Pharma qib |
| Qhov tshwm sim | Dawb hmoov |
| Assay | 99% |
| Txee lub neej | 2 xyoo |
| Ntim | 25kg / nruas |
| Qhov xwm txheej | Khaws ntawm -20 ° C |
Cov ntsiab lus
Tizanidine yog ib qho imidazoline ob nitrogen heterocyclic pentene derivative. Cov qauv zoo ib yam li cov clonidine. Nyob rau hauv 1987, nws yog thawj zaug teev nyob rau hauv Finland raws li ib tug central adrenalin α2 receptor agonist. Tam sim no, nws yog siv los ua lub hauv nruab nrab cov leeg nqaij so hauv tsev kho mob. Nws tuaj yeem siv los kho mob nqaij leeg, xws li caj dab lub duav thiab torticollis. Nws kuj tseem siv tau los kho mob tom qab phais, xws li disc herniation thiab mob caj dab. Nws los ntawm ankylosis ntawm neurological ntshawv siab, xws li ntau yam sclerosis, mob myelopathy, mob hlab ntsha tawg thiab lwm yam.
Muaj nuj nqi
Nws yog siv los txo cov leeg pob txha, cov leeg pob txha thiab myotonia los ntawm lub hlwb thiab txha caj qaum raug mob, cerebral hemorrhage, encephalitis thiab ntau yam sclerosis.
Pharmacology
Nws xaiv txo qhov tso tawm ntawm excitatory amino acids los ntawm interneurons thiab inhibits ntau synaptic mechanism cuam tshuam rau cov leeg nqaij overstrain. Cov khoom no tsis cuam tshuam rau kev sib kis ntawm neuromuscular. Nws yog zoo zam. Nws muaj txiaj ntsig zoo rau cov leeg mob hnyav thiab mob ankylosis los ntawm tus txha caj qaum thiab lub hlwb. Nws tuaj yeem txo qhov tsis kam ntawm kev txav mus los, txo qis spasticity thiab clonus, thiab ua kom muaj zog ntawm kev yeem txav mus los.
Siv
Sau npe Tizanidine, npaj rau siv los ua tus qauv sab hauv rau kev ntsuas Tizanidine los ntawm GC- lossis LC-mass spectrometry. Tizanidine tuaj yeem siv tshuaj kho raws li SARS-CoV-2 lub ntsiab protease inhibitor.
Kev siv tshuaj kho mob
Tizanidine yog lub hauv paus ua yeeb yam adrenergic α2 receptor agonist siv los kho cov leeg mob ntev, xws li ntau yam sclerosis.
Mechanism ntawm kev ua
Tizanidine yog ib qho tseem ceeb ntawm cov leeg nqaij relaxant analogue ntawm clonidine uas tau pom zoo siv los txo qhov spasticity txuam nrog cerebral lossis txha caj qaum. Nws mechanism ntawm kev txiav txim rau txo spasticity qhia presynaptic inhibition ntawm lub cev muaj zog neurons ntawm lubα2-adrenergic receptor qhov chaw, txo qhov tso tawm ntawm excitatory amino acids thiab inhibiting kev yooj yim ceruleospinal txoj kev, yog li ua rau txo qis spasticity. Tizanidine tsuas yog muaj ib feem me me ntawm cov tshuaj tiv thaiv kev mob ntshav siab ntawm clonidine, suav tias yog vim qhov kev txiav txim ntawm ib pawg neeg xaiv.α2C-adrenoceptors, uas tshwm sim los ua lub luag haujlwm rau kev ua haujlwm ntawm cov tshuaj loog thiab antispasmodic. Cov tshuaj imidazolineα2-Txiv neej (20).
