Lus piav qhia luv luv:
CAS Nr .: 69004-03-1
Cov mis mos molecular: C18H14F3N3O4S
Molecular Luj: 425.38
Chemical structure:
| Cov ntaub ntawv yooj yim | |
| Khoom npe | Toltrazuril |
| CAS Nr. | 69004-03-1 |
| Xim | Dawb los yog yuav luag dawb crystalline hmoov |
| Qib | Pub Qib |
| Cia | Muab kaw rau hauv qhuav, Chav Kub |
| Txee lub neej | 2 xyoo |
| Siv | Nyuj, qaib, dev, ntses, nees, npua |
| Pob | 25kg / hnabnruas |
Kev piav qhia
Toltrazuril (Baycox®, Procox®) yog ib qho tshuaj triazinon uas muaj dav-spectrum anticoccidial thiab antiprotozoalactivity. Nws tsis yog muag hauv Tebchaws Meskas, tab sis nws muaj nyob hauv lwm lub tebchaws. Nws yog active tiv thaiv ob qho tib si asexual thiab kev sib deev theem ntawm coccidia byinhibiting nuclear faib ntawm schizonts thiab microga-monts thiab phab ntsa tsim lub cev ntawm macrogamonts. Nws kuj tseem yuav pab tau rau kev kho mob ntawm neonatal porcinecoccidiosis, EPM, thiab canine hepatozoonosis.
Toltrazuril thiab nws cov metabolite ponazuril loj (toltrazuril sulfone, Marquis) yog triazine-based antiprotozoal tshuaj uas muaj cov haujlwm tshwj xeeb tiv thaiv kab mob apicomplexan coccidial. Toltrazuril tsis muaj nyob hauv Tebchaws Meskas.
Kev siv cov khoom
Swine: Toltrazuril tau pom tias yuav txo tau cov tsos mob ntawm coccidiosis hauv cov npua uas muaj kab mob hauv cov laus thaum ib lub qhov ncauj 20–30 mg/kg BWdose muab rau 3 mus rau 6-hnub npua (Driesen li al., 1995). Cov tsos mob tshwm sim tau raug txo los ntawm 71 mus rau 22% ntawm cov npua hauv plab, thiab raws plab thiab oocyst excretion kuj tau txo los ntawm kev kho qhov ncauj ib leeg. Cov khoom lag luam pom zoo nqa lub sijhawm 77-hnub rho tawm hauv tebchaws United Kingdom.
Calves thiab yaj: Toltrazuril yog siv los tiv thaiv cov tsos mob ntawm coccidiosis thiab txo cov coccidia los ntawm cov nyuj thiab yaj raws li kev kho mob ib zaug. Lub sijhawm rho nyiaj hauv tebchaws United Kingdom yog 63 thiab 42 hnub rau cov nyuj thiab yaj, raws li.
Cov dev: Rau hepatozoonosis, toltrazuril muab qhov ncauj ntawm 5 mg / kg BW txhua 12 teev rau 5 hnub lossis muab qhov ncauj ntawm 10 mg / kg BW txhua 12 teev rau 10 hnub ua rau tshem tawm cov tsos mob hauv cov dev uas muaj kab mob hauv 2-3 hnub ( Macintire et al., 2001). Hmoov tsis zoo, feem ntau cov dev kho mob rov qab los thiab thaum kawg tuag los ntawm hepatozoonosis. Hauv cov menyuam dev nrog Isospora sp. Kev kis kab mob, kev kho mob nrog 0.45 mg emodepside ua ke nrog 9 mg / kg BW toltrazuril (Procox®, Bayer Animal Health) txo qis fecal oocyst suav los ntawm 91.5–100%. Tsis muaj qhov sib txawv ntawm lub sijhawm raws plab thaum kev kho mob tau pib tom qab qhov pib ntawm cov tsos mob tshwm sim thaum muaj kab mob patent (Altreuther et al., 2011).
Miv: Hauv kittens sim kis Isospora spp., kev kho mob ib zaug ntawm qhov ncauj ntawm 0.9 mg emodepside ua ke nrog 18 mg / kg BW toltrazuril (Procox®, Bayer AnimalHealth) txo qis oocyst los ntawm 96.7-100% yog tias muab thaum lub sijhawm ua ntej. lub sijhawm (Petry et al., 2011).
Nees: Toltrazuril kuj tau siv los kho EPM. Cov tshuaj no muaj kev nyab xeeb, txawm tias thaum noj tshuaj ntau. Cov kev kho mob tam sim no pom zoo yog 5-10 mg / kg ntawm qhov ncauj rau 28 hnub. Txawm hais tias muaj txiaj ntsig zoo nrog toltrazuril, nws txoj kev siv tau poob qis hauv cov nees vim tias muaj lwm yam tshuaj zoo.
