Lus piav qhia luv luv:
CAS Nr .: 1197-18-8
Cov mis mos molecular: C8H15NO2
Molecular Luj: 157.21
Chemical structure:
| Cov ntaub ntawv yooj yim | |
| Khoom npe | Tranexamic Acid |
| Qib | Qib Tshuaj pleev ib ce |
| Qhov tshwm sim | Dawb los yog yuav luag dawb, crystalline hmoov |
| Assay | 99% |
| Txee lub neej | 2 xyoo |
| Ntim | 25kg / nruas |
| Chemical Properties | Nws yog dawb do soluble nyob rau hauv dej thiab nyob rau hauv glacial acetic acid thiab yog me ntsis soluble nyob rau hauv ethanol thiab xyaum insoluble nyob rau hauv ether |
Kev piav qhia
Tranexamic acid yog ib qho derivative ntawm aminomethylbenzoic acid, thiab ib hom tshuaj antifibrinolytic kom tsis txhob los ntshav. Lub hemostasis mechanism ntawm tranexamic acid zoo ib yam li aminocaproic acid thiab aminomethylbenzoic acid, tab sis cov nyhuv muaj zog dua. Lub zog yog 7 mus rau 10 npaug ntawm aminocaproic acid, 2 zaug ntawm aminomethylbenzoic acid, tab sis toxicity zoo ib yam.
Cov qauv tshuaj ntawm tranexamic acid zoo ib yam li lysine, kev sib tw inhibition ntawm plasmin thawj hauv fibrin adsorption, los tiv thaiv lawv cov kev ua, tiv thaiv fiber ntau cov protein kom tsis txhob degrade los ntawm plasmin thiab yaj, nws thiaj li ua tiav hemostasis. Muaj feem xyuam rau kev kho mob ntawm tus mob los yog mob ntev, hauv zos lossis cov kab mob tseem ceeb fiber ntau fibrinolytic hyperthyroidism tshwm sim los ntawm los ntshav, xws li obstetric hemorrhage, lub raum hemorrhage, hemorrhage ntawm hypertrophy ntawm prostate, hemophilia, pulmonary tuberculosis hemoptysis, lub plab ua haujlwm ntawm lub siab, spleen thiab lwm yam viscera hemorrhage; kuj tuaj yeem siv rau hauv kev phais thaum txawv txav los ntshav thiab lwm yam.
Clinical tranexamic acid muaj txiaj ntsig zoo rau kab kab mob kab mob, kab mob dermatitis thiab eczema, purpura yooj yim, mob urticaria, kev sib deev urticaria, tshuaj lom eruption thiab eruption. Thiab tseem muaj qee yam cuam tshuam rau erythroderma, scleroderma, systemic lupus erythematosus (SLE), Erythema multiforme, shingles thiab alopecia areata. Kev kho mob ntawm hereditary angioedema nyhuv kuj zoo. Hauv kev kho tus kab mob Chloasma, cov tshuaj dav dav siv tau li 3 lub lis piam, zoo heev 5 lub lis piam, ib chav kawm ntawm 60 hnub. Muab qhov ncauj hauv koob tshuaj 0.25 ~ 0.5 g, ib hnub 3 ~ 4 zaug. Qee tus neeg mob tuaj yeem xeev siab, qaug zog, pruritus, tsis xis nyob hauv plab, thiab raws plab tshwm sim tom qab tshem tawm cov tsos mob ploj mus.
Cov lus qhia
Ntau yam los ntshav tshwm sim los ntawm mob hnyav lossis mob ntev, hauv zos lossis cov kab mob hauv lub cev hyperfibrinolysis; Secondary hyperfibrinolytic xeev tshwm sim los ntawm disseminated intravascular coagulation. Feem ntau tsis txhob siv cov khoom no ua ntej heparinization.
Kev raug mob lossis phais los ntshav hauv cov ntaub so ntswg thiab cov kabmob uas muaj ntau cov plasminogen activators xws li prostate, urethra, ntsws, hlwb, tsev menyuam, qog adrenal, thiab thyroid.
Ib qho antagonist ntawm cov ntaub so ntswg plasminogen activator (t-PA), streptokinase, thiab urokinase.
Fibrinolytic hemorrhage tshwm sim los ntawm kev rho menyuam tawm, thaum ntxov placental detachment, stillbirth thiab amniotic kua embolism; thiab nce menorrhagia tshwm sim los ntawm pathological intrauterine fibrinolysis.
Cerebral neuropathy me me los ntshav, xws li subarachnoid hemorrhage thiab intracranial aneurysm hemorrhage, cov nyhuv ntawm Amstat nyob rau hauv cov mob no yog zoo dua li ntawm lwm yam anti-fibrinolytic agents. Kev saib xyuas tshwj xeeb yuav tsum tau them rau qhov kev pheej hmoo ntawm cerebral edema lossis cerebral infarction.Rau cov neeg mob hnyav nrog kev phais, cov khoom no tsuas yog siv tau los ua cov tshuaj ntxiv.
Rau kev kho mob ntawm hereditary angioneurotic edema, nws tuaj yeem txo tus naj npawb thiab qhov hnyav ntawm lub sijhawm.
Siv rau hauv cov neeg mob hemophilia rau lawv cov hemorrhage ua ke nrog lwm cov tshuaj.
Cov neeg mob Hemophilia uas muaj qhov muaj VIII lossis yam IX tsis txaus hauv lawv cov hniav rho tawm lossis phais qhov ncauj thaum ua haujlwm los ntshav.
